E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER

Yendri Januardi, Djonny Ferianto Pualilin, Indra Kadir, Prihantono Prihantono.

Abstract
Breast cancer was a type of malignancy that occurred in human breast organs in both ductal and lobule tissues. In Indonesia, more than 80% of the cases were found in an advanced stage, as prognosis became worse and therapy effectiveness was less. It was estimated, as many as 40% of Breast cancer patients died of metastatic factors. Therefore, examination of prognostic biomarkers of metastasis in breast cancer was critical. This study aimed to examine the relationship between the expression of E-cadherin and Her-2 /Neu with the incidence of distant metastases in breast cancer. This study was conducted using analytical observation method with cross-sectional study in 46 breast cancer patients who were both metastatic and not metastatic breast cancer patients at Dr. Wahidin Sudirohusodo Hospital Makassar. Research results showed that there was no significant relationship between tumor grading and incidence of metastasis (p> 0.05), but it was seen that the percentage of subjects with M1 was found to be higher at a moderate grade (69.2%) and high grade (46.7%) compared on low grade (40.0%). Also, it is known that there was a significant relationship between E-Cadherin expression and incidence of metastasis (p <0.001). In this study, the percentage of subjects with M1 was significantly higher in negative expression (91.3%) than in positive expression (26.1%). Conclussion : there was a significant relationship between decreased expression of E-Cadherin and incidence of distant metastasis in patients with breast cancer. However, there was no correlation between HER2 overexpression and the occurrence of distant metastasis in breast cancer patients, and there was no relationship between E-cadherin expression and HER2 expression.

Key words: E-cadherin, HER-2 / NEU, breast cancer, metastasis


 
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How to Cite this Article
Pubmed Style

Januardi Y, Pualilin DF, Kadir I, Prihantono P, . RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER. doi:10.5455/ijsm.ecadherin-her2-metastatic-breast-cancer


Web Style

Januardi Y, Pualilin DF, Kadir I, Prihantono P, . RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER. http://www.ejos.org/?mno=14020 [Access: March 24, 2019]. doi:10.5455/ijsm.ecadherin-her2-metastatic-breast-cancer


AMA (American Medical Association) Style

Januardi Y, Pualilin DF, Kadir I, Prihantono P, . RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER. doi:10.5455/ijsm.ecadherin-her2-metastatic-breast-cancer



Vancouver/ICMJE Style

Januardi Y, Pualilin DF, Kadir I, Prihantono P, . RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER. doi:10.5455/ijsm.ecadherin-her2-metastatic-breast-cancer



Harvard Style

Januardi, Y., Pualilin, . D. F., Kadir, . I., Prihantono, . P. & (2019) RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER. doi:10.5455/ijsm.ecadherin-her2-metastatic-breast-cancer



Turabian Style

Januardi, Yendri, Djonny Ferianto Pualilin, Indra Kadir, Prihantono Prihantono, and . 2019. RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER. doi:10.5455/ijsm.ecadherin-her2-metastatic-breast-cancer



Chicago Style

Januardi, Yendri, Djonny Ferianto Pualilin, Indra Kadir, Prihantono Prihantono, and . "RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER." doi:10.5455/ijsm.ecadherin-her2-metastatic-breast-cancer



MLA (The Modern Language Association) Style

Januardi, Yendri, Djonny Ferianto Pualilin, Indra Kadir, Prihantono Prihantono, and . "RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER." doi:10.5455/ijsm.ecadherin-her2-metastatic-breast-cancer



APA (American Psychological Association) Style

Januardi, Y., Pualilin, . D. F., Kadir, . I., Prihantono, . P. & (2019) RELATIONSHIP AMONG EXPRESSION OF E-CADHERIN AND HER-2/NEU WITH METASTASIS IN BREAST CANCER. doi:10.5455/ijsm.ecadherin-her2-metastatic-breast-cancer