E-ISSN 2367-699X | ISSN 2367-7414
 

Case Report 


Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report

Tommy Sarongku, I Gusti Gede Ariswanda, I Ketut Sumada, Ketut Candra Wiratni, I Putu Eka Widyadharma.

Abstract
Cerebral toxoplasmosis is an opportunistic infection in HIV with CD4 T-cells below < 200/uL. The aetiology is Toxoplasma gondii. Trimethoprim plus sulfamethoxazole (cotrimoxazole) combined pyrimethamine is the first line for the treatment of cerebral toxoplasmosis in immunodeficiency. The second line for treatment is clindamycin combined pyrimethamine in Indonesia.
We reported a 48-year-old woman as diagnosed retroviral infection referred to Wangaya General Hospital, with main complaints of vomiting and severe headache. The blood test showed normal limits except lymphocyte account. IgM antibody for toxoplasmosis raised. Brain computed tomography-scan showed a cystic lesion in right basal ganglia with ring-enhancing surrounding by finger-like oedema. She treated with pyrimethamine and cotrimoxazole. The patient had a reddish rash on the skin with thrombocytopenia during 7-day on treatment suspected sulfa and pyrimethamine adverse side effect. Patient treated clindamycin as single therapy for cerebral toxoplasmosis. Her headache is better within two weeks of admission. Thirty days later the patient was repeated brain-CT scan, and the mass was found to be smaller.
Conclusions: Single-therapy with clindamycin in CNS toxoplasmosis showed good outcome in resource-poor setting and history of sulfonamide allergy.

Key words: HIV, Cerebral toxoplasmosis, Clindamycin, Sulfa Allergy


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Tommy Sarongku
Articles by I Gusti Gede Ariswanda
Articles by I Ketut Sumada
Articles by Ketut Candra Wiratni
Articles by I Putu Eka Widyadharma
on Google
on Google Scholar
Article Statistics
 Viewed: 728
Downloaded: 21
Cited: 0


How to Cite this Article
Pubmed Style

Sarongku T, Ariswanda IGG, Sumada IK, Wiratni KC, Widyadharma IPE. Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report. Int J Surg Med. 2019; 5(3): 163-165. doi:10.5455/ijsm.Case-Report-Neuroinfection


Web Style

Sarongku T, Ariswanda IGG, Sumada IK, Wiratni KC, Widyadharma IPE. Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report. http://www.ejos.org/?mno=31785 [Access: September 17, 2019]. doi:10.5455/ijsm.Case-Report-Neuroinfection


AMA (American Medical Association) Style

Sarongku T, Ariswanda IGG, Sumada IK, Wiratni KC, Widyadharma IPE. Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report. Int J Surg Med. 2019; 5(3): 163-165. doi:10.5455/ijsm.Case-Report-Neuroinfection



Vancouver/ICMJE Style

Sarongku T, Ariswanda IGG, Sumada IK, Wiratni KC, Widyadharma IPE. Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report. Int J Surg Med. (2019), [cited September 17, 2019]; 5(3): 163-165. doi:10.5455/ijsm.Case-Report-Neuroinfection



Harvard Style

Sarongku, T., Ariswanda, . I. G. G., Sumada, . I. K., Wiratni, . K. C. & Widyadharma, . I. P. E. (2019) Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report. Int J Surg Med, 5 (3), 163-165. doi:10.5455/ijsm.Case-Report-Neuroinfection



Turabian Style

Sarongku, Tommy, I Gusti Gede Ariswanda, I Ketut Sumada, Ketut Candra Wiratni, and I Putu Eka Widyadharma. 2019. Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report. International Journal of Surgery and Medicine, 5 (3), 163-165. doi:10.5455/ijsm.Case-Report-Neuroinfection



Chicago Style

Sarongku, Tommy, I Gusti Gede Ariswanda, I Ketut Sumada, Ketut Candra Wiratni, and I Putu Eka Widyadharma. "Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report." International Journal of Surgery and Medicine 5 (2019), 163-165. doi:10.5455/ijsm.Case-Report-Neuroinfection



MLA (The Modern Language Association) Style

Sarongku, Tommy, I Gusti Gede Ariswanda, I Ketut Sumada, Ketut Candra Wiratni, and I Putu Eka Widyadharma. "Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report." International Journal of Surgery and Medicine 5.3 (2019), 163-165. Print. doi:10.5455/ijsm.Case-Report-Neuroinfection



APA (American Psychological Association) Style

Sarongku, T., Ariswanda, . I. G. G., Sumada, . I. K., Wiratni, . K. C. & Widyadharma, . I. P. E. (2019) Clindamycin as single therapy for cerebral toxoplasmosis HIV in the history of sulfa allergy: A Case Report. International Journal of Surgery and Medicine, 5 (3), 163-165. doi:10.5455/ijsm.Case-Report-Neuroinfection