E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study

Mahim Koshariya, Alex Sharon, M.C. Songra, Shikha Shukla, Vidhu Khare, Kunal Vaidya, Fahad Ansari.

Abstract
Background: Using Faecal DNA test to detect these aberrant methylations and mutations in DNA shed from the colonic cells could help in detection of pre-cancerous or early stage of colorectal cancer which would improve the mortality rate. Guaiac based chemical detection of faecal occult blood (gFOBT) is one of the non-invasive screening methods but with lower sensitivity as not every colorectal cancerous lesion bleeds.
Aims :To compare the sensitivity and specificity of stool DNA test against Faecal Occult Blood Test.
Method: This was a prospective case control study to compare the sensitivity and specificity of Faecal DNA test with gFOBT as to which test would make a better screening tool for colorectal cancer.
Result: The sensitivity of Faecal DNA Test was found to be 86% whereas the sensitivity of gFOBT was found to be 66% and specificity for gFOBT was 86% compared to 72% for Faecal DNA test.
Conclusion: Based on several studies including the present study it could be concluded that there is sufficient data to include Faecal DNA test as a viable option for CRC screening although testing stool for molecular markers is an evolving technology

Key words: Colorectal cancer (CRC), screening, Faecal DNA test/ Stool DNA test (sDNA), Guaiac based faecal occult blood (gFOBT), Sensitivity, Specificity


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Mahim Koshariya
Articles by Alex Sharon
Articles by M.C. Songra
Articles by Shikha Shukla
Articles by Vidhu Khare
Articles by Kunal Vaidya
Articles by Fahad Ansari
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Koshariya M, Sharon A, Songra M, Shukla S, Khare V, Vaidya K, Ansari F. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. Int J Surg Med. 2020; 6(4): 38-43. doi:10.5455/ijsm.2020-07-056


Web Style

Koshariya M, Sharon A, Songra M, Shukla S, Khare V, Vaidya K, Ansari F. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. http://www.ejos.org/?mno=36615 [Access: September 19, 2020]. doi:10.5455/ijsm.2020-07-056


AMA (American Medical Association) Style

Koshariya M, Sharon A, Songra M, Shukla S, Khare V, Vaidya K, Ansari F. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. Int J Surg Med. 2020; 6(4): 38-43. doi:10.5455/ijsm.2020-07-056



Vancouver/ICMJE Style

Koshariya M, Sharon A, Songra M, Shukla S, Khare V, Vaidya K, Ansari F. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. Int J Surg Med. (2020), [cited September 19, 2020]; 6(4): 38-43. doi:10.5455/ijsm.2020-07-056



Harvard Style

Koshariya, M., Sharon, . A., Songra, . M., Shukla, . S., Khare, . V., Vaidya, . K. & Ansari, . F. (2020) Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. Int J Surg Med, 6 (4), 38-43. doi:10.5455/ijsm.2020-07-056



Turabian Style

Koshariya, Mahim, Alex Sharon, M.C. Songra, Shikha Shukla, Vidhu Khare, Kunal Vaidya, and Fahad Ansari. 2020. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. International Journal of Surgery and Medicine, 6 (4), 38-43. doi:10.5455/ijsm.2020-07-056



Chicago Style

Koshariya, Mahim, Alex Sharon, M.C. Songra, Shikha Shukla, Vidhu Khare, Kunal Vaidya, and Fahad Ansari. "Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study." International Journal of Surgery and Medicine 6 (2020), 38-43. doi:10.5455/ijsm.2020-07-056



MLA (The Modern Language Association) Style

Koshariya, Mahim, Alex Sharon, M.C. Songra, Shikha Shukla, Vidhu Khare, Kunal Vaidya, and Fahad Ansari. "Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study." International Journal of Surgery and Medicine 6.4 (2020), 38-43. Print. doi:10.5455/ijsm.2020-07-056



APA (American Psychological Association) Style

Koshariya, M., Sharon, . A., Songra, . M., Shukla, . S., Khare, . V., Vaidya, . K. & Ansari, . F. (2020) Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. International Journal of Surgery and Medicine, 6 (4), 38-43. doi:10.5455/ijsm.2020-07-056