E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia

Ibrahim Labeda, Erwin Syarifuddin, Julianus Aboyaman Uwuratuw, Ilham Jaya Pattelongi, Muhammad Faruk.

Abstract
Introduction: Phosphatidylinositol 3-Kinase (PI3KCA) were signal pathways that play important roles in cell proliferation, resistance to apoptosis, angiogenesis, and metastasis in CRC. The effect of PI3K in the growth and development of tumor was mediated by Akt (Kinase serine-threonine) and was correlated with cell proliferation, apoptosis inhibition, and clinicopathological parameter difference. There is currently no data on PI3KCA to Colorectal Cancer clinicopathology in Makassar.
Methods: This is an observational study with a cross-sectional design. As many as 55 samples fulfilled inclusion criteria and were subjected to immunohistochemistry examination using PIK3CA Monoclonal Antibody with semiquantitative analysis. Data were analyzed with the Chi-Square test and Fisher’s exact test.
Results: Analyzed between PI3KCA expression and Clinicopathology features was not one negative PI3KCA expression was found in the right colon. Meanwhile, 30.8% positive PI3KCA expression was found in right colon (p = 0.009). Similar results were found in the histopathological type. Not one negative PI3KCA expression was found in mucinous histopathological type, while 28.2% positive PI3KCA expression was found (p = 0.014).
Conclusion: Frequency of PI3KCA mutation was 70.9% out of total samples of CRC patients in Makassar. PI3KCA expression was found to be significantly related to tumor location and histopathological type but insignificantly related to the clinical stage.

Key words: PI3KCA, PI3K, Phosphatidylinositol, Clinicopathology, Colorectal Cancer


 
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How to Cite this Article
Pubmed Style

Labeda I, ES, Uwuratuw JA, Pattelongi IJ, Faruk M. Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia. Int J Surg Med. 2020; 6(1): 48-52. doi:10.5455/ijsm.PI3K-colorectal-cancer


Web Style

Labeda I, ES, Uwuratuw JA, Pattelongi IJ, Faruk M. Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia. http://www.ejos.org/?mno=65553 [Access: September 21, 2020]. doi:10.5455/ijsm.PI3K-colorectal-cancer


AMA (American Medical Association) Style

Labeda I, ES, Uwuratuw JA, Pattelongi IJ, Faruk M. Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia. Int J Surg Med. 2020; 6(1): 48-52. doi:10.5455/ijsm.PI3K-colorectal-cancer



Vancouver/ICMJE Style

Labeda I, ES, Uwuratuw JA, Pattelongi IJ, Faruk M. Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia. Int J Surg Med. (2020), [cited September 21, 2020]; 6(1): 48-52. doi:10.5455/ijsm.PI3K-colorectal-cancer



Harvard Style

Labeda, I., , . E. S., Uwuratuw, . J. A., Pattelongi, . I. J. & Faruk, . M. (2020) Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia. Int J Surg Med, 6 (1), 48-52. doi:10.5455/ijsm.PI3K-colorectal-cancer



Turabian Style

Labeda, Ibrahim, Erwin Syarifuddin, Julianus Aboyaman Uwuratuw, Ilham Jaya Pattelongi, and Muhammad Faruk. 2020. Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia. International Journal of Surgery and Medicine, 6 (1), 48-52. doi:10.5455/ijsm.PI3K-colorectal-cancer



Chicago Style

Labeda, Ibrahim, Erwin Syarifuddin, Julianus Aboyaman Uwuratuw, Ilham Jaya Pattelongi, and Muhammad Faruk. "Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia." International Journal of Surgery and Medicine 6 (2020), 48-52. doi:10.5455/ijsm.PI3K-colorectal-cancer



MLA (The Modern Language Association) Style

Labeda, Ibrahim, Erwin Syarifuddin, Julianus Aboyaman Uwuratuw, Ilham Jaya Pattelongi, and Muhammad Faruk. "Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia." International Journal of Surgery and Medicine 6.1 (2020), 48-52. Print. doi:10.5455/ijsm.PI3K-colorectal-cancer



APA (American Psychological Association) Style

Labeda, I., , . E. S., Uwuratuw, . J. A., Pattelongi, . I. J. & Faruk, . M. (2020) Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia. International Journal of Surgery and Medicine, 6 (1), 48-52. doi:10.5455/ijsm.PI3K-colorectal-cancer