E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center

Subrat Kumar Samantara, Kusumbati Besra, Padmalaya Devi, Sagarika Samantaray, Sashibhusan Dash.

Abstract
Introduction: Breast cancer among young women is found to have a more aggressive behaviour and trends to be diagnosed at an advanced stage but the reason still remains unclear. This study aims to evaluate the clinicohistopathological characteristics of breast carcinoma ≤40 years in comparison to that over >40 years ago. Methods: Hospital-based retrospective study was done over a period of three years from January 2017 to December 2019 at Acharya Harihar Post Graduate Institute of Cancer, Cuttack. Patients who were diagnosed with breast carcinoma and subsequent underwent breast surgery were included. The cases were divided into a “young” ≤40 years group and an “older” >40 years group. Clinicohistopathological parameters such as age, sex, tumour site, tumour size, tumour type, tumour grade, lymphovascular invasion (LVSI), perineural invasion (PNI), presence of tumour necrosis, T stage, nodal positivity, hormonal expression were retrieved from the hospital record. Results: A total of 589 patients were included during this study period, out of which 166 (28.18%) were ≤40 years and 423 (71.81%) were >40 years ago. Compared with the elderly patients,89 (53.61%) breast cancer in young patients were poorly differentiated(P=0.0000606; significant). One hundred and sixteen patients (69.87%) presented with T3/T4 as compared to 240 (56.73%)patients in the above >40 years age group. (P= 0.0033; significant). The double-positive expression of the estrogen receptor (ER) and PR (i.e., ER+/PR+) in the two groups were 63 (37.95%) and 225 (53.19%) respectively. However, 46 (27.71)% of patients were triple-negative in the ≤40 years age group versus 84 (18.85%) in the >40 years age group. Conclusion: Younger age patients were associated with high tumour grade, stage, PNI, LVSI, tumour necrosis, the negative status of progesterone (PR) and estrogen receptor (ER), and triple-negative subtype of the tumour. 

Key words: Breast cancer, young patients, histopathological characteristics, prognostic factors


 
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How to Cite this Article
Pubmed Style

Samantara SK, Besra K, Devi P, Samantaray S, Dash S. The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center. Int J Surg Med. 2021; 7(2): 28-33. doi:10.5455/ijsm.breast-cancer-young40


Web Style

Samantara SK, Besra K, Devi P, Samantaray S, Dash S. The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center. http://www.ejos.org/?mno=38797 [Access: May 19, 2021]. doi:10.5455/ijsm.breast-cancer-young40


AMA (American Medical Association) Style

Samantara SK, Besra K, Devi P, Samantaray S, Dash S. The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center. Int J Surg Med. 2021; 7(2): 28-33. doi:10.5455/ijsm.breast-cancer-young40



Vancouver/ICMJE Style

Samantara SK, Besra K, Devi P, Samantaray S, Dash S. The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center. Int J Surg Med. (2021), [cited May 19, 2021]; 7(2): 28-33. doi:10.5455/ijsm.breast-cancer-young40



Harvard Style

Samantara, S. K., Besra, . K., Devi, . P., Samantaray, . S. & Dash, . S. (2021) The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center. Int J Surg Med, 7 (2), 28-33. doi:10.5455/ijsm.breast-cancer-young40



Turabian Style

Samantara, Subrat Kumar, Kusumbati Besra, Padmalaya Devi, Sagarika Samantaray, and Sashibhusan Dash. 2021. The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center. International Journal of Surgery and Medicine, 7 (2), 28-33. doi:10.5455/ijsm.breast-cancer-young40



Chicago Style

Samantara, Subrat Kumar, Kusumbati Besra, Padmalaya Devi, Sagarika Samantaray, and Sashibhusan Dash. "The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center." International Journal of Surgery and Medicine 7 (2021), 28-33. doi:10.5455/ijsm.breast-cancer-young40



MLA (The Modern Language Association) Style

Samantara, Subrat Kumar, Kusumbati Besra, Padmalaya Devi, Sagarika Samantaray, and Sashibhusan Dash. "The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center." International Journal of Surgery and Medicine 7.2 (2021), 28-33. Print. doi:10.5455/ijsm.breast-cancer-young40



APA (American Psychological Association) Style

Samantara, S. K., Besra, . K., Devi, . P., Samantaray, . S. & Dash, . S. (2021) The pattern of histopathological presentation in younger (< 40 years) and elder age(>40 years) breast cancer patients: a retrospective study from a tertiary cancer center. International Journal of Surgery and Medicine, 7 (2), 28-33. doi:10.5455/ijsm.breast-cancer-young40