E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast

Mukunda Krishnamurthy Namagondlu, Shrivastava R K.

Abstract
Background: Angiogenesis is a necessary step in the growth of any tumour and metastasis. Vascular endothelial growth factor (VEGF) is a major mediator of breast cancer angiogenesis. The expression of VEGF by breast tumours has been previously correlated with a poor prognosis in the pathogenesis of breast cancer.
Method: In this cross-sectional descriptive study 54 women were enrolled over the period of 2 years. This study was aimed to determine the correlation between serum and tissue levels of VEGF-A and prognosis in carcinoma of breast cases. It also tried to correlate the aggressiveness of the disease with serum and tissue levels of VEGF-A in the subject population.
Results: In benign cases, preoperative serum VEGF-A (sVEGF-A) levels remained within 3000 pg/ml while post-operative sVEGF-A levels never went beyond 2300pg/ml. In the majority of carcinoma breast cases, preoperative sVEGF-A levels remain within 4000 pg/ml while post-operative sVEGF-A levels never went beyond 3000pg/ml. All the benign lesions were negative for tissue VEGF-A (tVEGF-A). While all malignant lesions were positive for tVEGF-A in the immunohistochemistry (IHC) study. Patients with a malignant lesion of higher tumour grades were having high tVEGF-A readings (2+ or more). In this study higher nodal status was associated with higher tVEGF-A reading. Similarly, tVEGF-A was higher in ER/PR/Her2neu negative cases.
Conclusions: Determination of VEGF-A can be considered a promising, but investigative and prognostic tool. Large prospective studies are necessary to better define the relationship of prognosis to angiogenesis and VEGF-A.

Key words: carcinoma breast, prognostic markers, VEGF-A


 
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How to Cite this Article
Pubmed Style

Namagondlu MK, K SR. Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast. Int J Surg Med. 2021; 7(3): 29-34. doi:10.5455/ijsm.Vascular-Endothelial-Growth-Factor-A-breast-cancer-284


Web Style

Namagondlu MK, K SR. Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast. http://www.ejos.org/?mno=44481 [Access: August 03, 2021]. doi:10.5455/ijsm.Vascular-Endothelial-Growth-Factor-A-breast-cancer-284


AMA (American Medical Association) Style

Namagondlu MK, K SR. Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast. Int J Surg Med. 2021; 7(3): 29-34. doi:10.5455/ijsm.Vascular-Endothelial-Growth-Factor-A-breast-cancer-284



Vancouver/ICMJE Style

Namagondlu MK, K SR. Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast. Int J Surg Med. (2021), [cited August 03, 2021]; 7(3): 29-34. doi:10.5455/ijsm.Vascular-Endothelial-Growth-Factor-A-breast-cancer-284



Harvard Style

Namagondlu, M. K. & K, . S. R. (2021) Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast. Int J Surg Med, 7 (3), 29-34. doi:10.5455/ijsm.Vascular-Endothelial-Growth-Factor-A-breast-cancer-284



Turabian Style

Namagondlu, Mukunda Krishnamurthy, and Shrivastava R K. 2021. Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast. International Journal of Surgery and Medicine, 7 (3), 29-34. doi:10.5455/ijsm.Vascular-Endothelial-Growth-Factor-A-breast-cancer-284



Chicago Style

Namagondlu, Mukunda Krishnamurthy, and Shrivastava R K. "Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast." International Journal of Surgery and Medicine 7 (2021), 29-34. doi:10.5455/ijsm.Vascular-Endothelial-Growth-Factor-A-breast-cancer-284



MLA (The Modern Language Association) Style

Namagondlu, Mukunda Krishnamurthy, and Shrivastava R K. "Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast." International Journal of Surgery and Medicine 7.3 (2021), 29-34. Print. doi:10.5455/ijsm.Vascular-Endothelial-Growth-Factor-A-breast-cancer-284



APA (American Psychological Association) Style

Namagondlu, M. K. & K, . S. R. (2021) Vascular Endothelial Growth Factor-A (VEGF-A) as a Prognostic Marker in Cases of Carcinoma Breast. International Journal of Surgery and Medicine, 7 (3), 29-34. doi:10.5455/ijsm.Vascular-Endothelial-Growth-Factor-A-breast-cancer-284