E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence.

Cited by (1)

Abstract
Objectives: In the present study, we aimed to determine the prevalence of aspirin resistance in patients with Type 1 and 2 diabetes and to study its association with metabolic parameters.
Methods: Aspirin resistance of patients (n=158) with Type 2 Diabetes Mellitus (DM) who presented to the center after 7 days of regular aspirin use were compared to age-mathced (5519) healthy controls (n=164). Similarly, aspirin resistance of patients (n=30) diagnosed with Type 1 DM were compared to age-matched (277) healthy subjects (n=41) as the control group. Platelet Function Analyzer (PFA)-100 was used to evaluate the efficacy of aspirin.
Results: Aspirin resistance was identified in 72 of 158 patients with Type 2 DM (45.6%) and in 47 of 164 healthy controls (28.6%) (p=0.001). Aspirin resistance had a prevalence of 50% in patients with Type 1 DM and was significantly higher compared to the control group of 41 healthy subjects (12.2%) (p=0.001). No correlations were noted between aspirin resistance and sex, smoking, HbA1c, hypertension and aspirin dose. There was a significant relation between aspirin resistance and LDL-cholesterol in patients with Type 2 DM (p=0.020).
Conclusion: Patients with Type 1 and Type 2 DM had a higher frequency of aspirin resistance than the control group. Therefore, treatment choices including administering higher doses of aspirin or using other antiplatelet agents such as clopidogrel should be considered to prevent thrombocytic events in diabetes mellitus.

Key words: Type 1 Diabetes, Type 2 Diabetes, Aspirin resistance.


 
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1
 
How to Cite this Article
Pubmed Style

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence. FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS. Int J Surg Med. 2016; 2(3): 122-126. doi:10.5455/ijsm.aspirin-resistance-diabetes


Web Style

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence. FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS. http://www.ejos.org/?mno=229387 [Access: August 21, 2019]. doi:10.5455/ijsm.aspirin-resistance-diabetes


AMA (American Medical Association) Style

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence. FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS. Int J Surg Med. 2016; 2(3): 122-126. doi:10.5455/ijsm.aspirin-resistance-diabetes



Vancouver/ICMJE Style

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence. FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS. Int J Surg Med. (2016), [cited August 21, 2019]; 2(3): 122-126. doi:10.5455/ijsm.aspirin-resistance-diabetes



Harvard Style

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence (2016) FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS. Int J Surg Med, 2 (3), 122-126. doi:10.5455/ijsm.aspirin-resistance-diabetes



Turabian Style

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence. 2016. FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS. International Journal of Surgery and Medicine, 2 (3), 122-126. doi:10.5455/ijsm.aspirin-resistance-diabetes



Chicago Style

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence. "FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS." International Journal of Surgery and Medicine 2 (2016), 122-126. doi:10.5455/ijsm.aspirin-resistance-diabetes



MLA (The Modern Language Association) Style

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence. "FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS." International Journal of Surgery and Medicine 2.3 (2016), 122-126. Print. doi:10.5455/ijsm.aspirin-resistance-diabetes



APA (American Psychological Association) Style

Deniz Gokalp, Alpaslan Tuzcu, Ster Irmak, Mithat Bahceci, Ozlem Demirpence (2016) FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH TYPE 1 AND 2 DIABETES MELLITUS AND ITS ASSOCIATION WITH METABOLIC PARAMETERS. International Journal of Surgery and Medicine, 2 (3), 122-126. doi:10.5455/ijsm.aspirin-resistance-diabetes