E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


Free radical scavenging activity of Berberine in acetaminophen induced liver injury

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo.

Abstract
ABSTRACT
Objective: Evaluation of free radical scavenging activity of Berberine (BBR) in acetaminophen (AAP) induced liver injury.
Study design: Experimental study
Place and Duration: Animal house, Isra University Hyderabad from October 2015 to March 2016.
Methodology: A sample of 80 male Wistar rats was selected according to inclusion and exclusion criteria and was divided into a control and three experimental groups. Acetaminophen, N-acetyl cysteine (NAC) and BBR were administered in standard doses. Blood samples were collected by cardiac puncture after 18 hours of post experiment period. Liver function test, anti oxidant enzymes and malondialdehyde (MDA) were detected by ELISA assay kit (Fortress Diagnostics). The data was analyzed on Statistix 10.0 software (USA) at 95% CI (P≤ 0.05).
Results: The BBR showed anti oxidant and anti peroxidant activity against acetaminophen induced liver injury. BBR treated animals showed increased serum and tissue SOD, GPX, CAT, and GSSH with a reduction in tissue MDA (p=0.0001). Liver injury ameliorating effect of BBR was superior to N-acetyl cysteine.
Conclusion: The present study suggests Berberine protects against acetaminophen-induced liver injury by its free radical scavenging activity.

Key words: Berberine N-acetyl cysteine Acetaminophen Free radical


 
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How to Cite this Article
Pubmed Style

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo. Free radical scavenging activity of Berberine in acetaminophen induced liver injury. Int J Surg Med. 2017; 3(1): 27-36. doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury


Web Style

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo. Free radical scavenging activity of Berberine in acetaminophen induced liver injury. http://www.ejos.org/?mno=251712 [Access: June 19, 2019]. doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury


AMA (American Medical Association) Style

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo. Free radical scavenging activity of Berberine in acetaminophen induced liver injury. Int J Surg Med. 2017; 3(1): 27-36. doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury



Vancouver/ICMJE Style

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo. Free radical scavenging activity of Berberine in acetaminophen induced liver injury. Int J Surg Med. (2017), [cited June 19, 2019]; 3(1): 27-36. doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury



Harvard Style

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo (2017) Free radical scavenging activity of Berberine in acetaminophen induced liver injury. Int J Surg Med, 3 (1), 27-36. doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury



Turabian Style

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo. 2017. Free radical scavenging activity of Berberine in acetaminophen induced liver injury. International Journal of Surgery and Medicine, 3 (1), 27-36. doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury



Chicago Style

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo. "Free radical scavenging activity of Berberine in acetaminophen induced liver injury." International Journal of Surgery and Medicine 3 (2017), 27-36. doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury



MLA (The Modern Language Association) Style

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo. "Free radical scavenging activity of Berberine in acetaminophen induced liver injury." International Journal of Surgery and Medicine 3.1 (2017), 27-36. Print. doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury



APA (American Psychological Association) Style

Suhail Ahmed Almani, Fatima Qureshi, Tariq Zaffar Shaikh, Arslan Ahmed Uqaili, Haji Khan Khoharo (2017) Free radical scavenging activity of Berberine in acetaminophen induced liver injury. International Journal of Surgery and Medicine, 3 (1), 27-36. doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury