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Original Article
Online Published: 31 Jan 2016
 


CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup.


Cited By: 2

Abstract
Background: Axillary lymph node status is the most important breast cancer prognostic factor. Preoperative axillary ultrasound examination (PAUS) is used to triage patients for sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND). We assessed the detection rate of lymph node metastases by PAUS in a screening unit and evaluated associations between clinicopathological factors and PAUS positivity.
Patients and Methods: This was a single-centre retrospective analysis of data extracted from a hospital breast cancer database and clinical records. Clinical, radiological, and pathological and prognostic indices were compared between PAUS-positive and PAUS-negative patients subsequently found to have lymph node metastases on histopathological analysis.
Results: Two hundred and two patients were eligible for analysis. 50.5% of lymph node-positive patients were correctly identified as PAUS positive. Patients with PAUS-positive lymph nodes had less favorable disease characteristics, namely clinically palpable lymph nodes, higher Nottingham prognostic (NPI) index, high lymph node burden according to the European Society of Medical Oncology (ESMO) group classification, and larger, grade 3 tumors with lymphovascular invasion and extranodal spread. Moreover, PAUS-positive patients had more macrometastases and lymph node involvement than PAUS-negative patients.
Conclusion: PAUS-positive patients and PAUS-negative (SLNB-positive) patients have different clinicopathological characteristics. The presence of LVI, extranodal spread, grade 3 histology, or large tumors with poor prognostic indices in PAUS-negative patients should be regarded with caution and perhaps prompt second-look ultrasound examination.

Key words: Preoperative axillary ultrasound scan; sentinel lymph node biopsy; breast cancer


 
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How to Cite this Article
Pubmed Style

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup. CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS. Int J Surg Med. 2016; 2(1): 23-29. doi:10.5455/ijsm.breastcancer

Web Style

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup. CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS. https://www.ejos.org/?mno=208901 [Access: September 12, 2024]. doi:10.5455/ijsm.breastcancer

AMA (American Medical Association) Style

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup. CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS. Int J Surg Med. 2016; 2(1): 23-29. doi:10.5455/ijsm.breastcancer


Vancouver/ICMJE Style

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup. CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS. Int J Surg Med. (2016), [cited September 12, 2024]; 2(1): 23-29. doi:10.5455/ijsm.breastcancer


Harvard Style

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup (2016) CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS. Int J Surg Med, 2 (1), 23-29. doi:10.5455/ijsm.breastcancer


Turabian Style

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup. 2016. CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS. International Journal of Surgery and Medicine, 2 (1), 23-29. doi:10.5455/ijsm.breastcancer


Chicago Style

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup. "CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS." International Journal of Surgery and Medicine 2 (2016), 23-29. doi:10.5455/ijsm.breastcancer


MLA (The Modern Language Association) Style

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup. "CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS." International Journal of Surgery and Medicine 2.1 (2016), 23-29. Print. doi:10.5455/ijsm.breastcancer


APA (American Psychological Association) Style

Lona Jalini, Dave Fok Nam Fung, Kaushik Kumar Dasgupta, Vijay Kurup (2016) CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH POSITIVE PREOPERATIVE AXILLARY ULTRASOUND SCANNING IN BREAST CANCER PATIENTS. International Journal of Surgery and Medicine, 2 (1), 23-29. doi:10.5455/ijsm.breastcancer


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