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Original Research
Online Published: 18 Aug 2020
 


Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study

Mahim Koshariya, Alex Sharon, M.C. Songra, Shikha Shukla, Vidhu Khare, Kunal Vaidya, Fahad Ansari.


Abstract
Background: Using Faecal DNA test to detect these aberrant methylations and mutations in DNA shed from the colonic cells could help in detection of pre-cancerous or early stage of colorectal cancer which would improve the mortality rate. Guaiac based chemical detection of faecal occult blood (gFOBT) is one of the non-invasive screening methods but with lower sensitivity as not every colorectal cancerous lesion bleeds.
Aims :To compare the sensitivity and specificity of stool DNA test against Faecal Occult Blood Test.
Method: This was a prospective case control study to compare the sensitivity and specificity of Faecal DNA test with gFOBT as to which test would make a better screening tool for colorectal cancer.
Result: The sensitivity of Faecal DNA Test was found to be 86% whereas the sensitivity of gFOBT was found to be 66% and specificity for gFOBT was 86% compared to 72% for Faecal DNA test.
Conclusion: Based on several studies including the present study it could be concluded that there is sufficient data to include Faecal DNA test as a viable option for CRC screening although testing stool for molecular markers is an evolving technology

Key words: Colorectal cancer (CRC), screening, Faecal DNA test/ Stool DNA test (sDNA), Guaiac based faecal occult blood (gFOBT), Sensitivity, Specificity


 
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How to Cite this Article
Pubmed Style

Koshariya M, Sharon A, Songra M, Shukla S, Khare V, Vaidya K, Ansari F. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. Int J Surg Med. 2020; 6(4): 38-43. doi:10.5455/ijsm.2020-07-056

Web Style

Koshariya M, Sharon A, Songra M, Shukla S, Khare V, Vaidya K, Ansari F. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. https://www.ejos.org/?mno=36615 [Access: September 13, 2024]. doi:10.5455/ijsm.2020-07-056

AMA (American Medical Association) Style

Koshariya M, Sharon A, Songra M, Shukla S, Khare V, Vaidya K, Ansari F. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. Int J Surg Med. 2020; 6(4): 38-43. doi:10.5455/ijsm.2020-07-056


Vancouver/ICMJE Style

Koshariya M, Sharon A, Songra M, Shukla S, Khare V, Vaidya K, Ansari F. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. Int J Surg Med. (2020), [cited September 13, 2024]; 6(4): 38-43. doi:10.5455/ijsm.2020-07-056


Harvard Style

Koshariya, M., Sharon, . A., Songra, . M., Shukla, . S., Khare, . V., Vaidya, . K. & Ansari, . F. (2020) Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. Int J Surg Med, 6 (4), 38-43. doi:10.5455/ijsm.2020-07-056


Turabian Style

Koshariya, Mahim, Alex Sharon, M.C. Songra, Shikha Shukla, Vidhu Khare, Kunal Vaidya, and Fahad Ansari. 2020. Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. International Journal of Surgery and Medicine, 6 (4), 38-43. doi:10.5455/ijsm.2020-07-056


Chicago Style

Koshariya, Mahim, Alex Sharon, M.C. Songra, Shikha Shukla, Vidhu Khare, Kunal Vaidya, and Fahad Ansari. "Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study." International Journal of Surgery and Medicine 6 (2020), 38-43. doi:10.5455/ijsm.2020-07-056


MLA (The Modern Language Association) Style

Koshariya, Mahim, Alex Sharon, M.C. Songra, Shikha Shukla, Vidhu Khare, Kunal Vaidya, and Fahad Ansari. "Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study." International Journal of Surgery and Medicine 6.4 (2020), 38-43. Print. doi:10.5455/ijsm.2020-07-056


APA (American Psychological Association) Style

Koshariya, M., Sharon, . A., Songra, . M., Shukla, . S., Khare, . V., Vaidya, . K. & Ansari, . F. (2020) Faecal DNA Testing for Detection of Colorectal Carcinoma: A Prospective Case Control Study. International Journal of Surgery and Medicine, 6 (4), 38-43. doi:10.5455/ijsm.2020-07-056


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