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Original Research
Online Published: 11 Nov 2018
 


METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY

Ksenya Komshilova, Natalya Mazurina, Ekaterina Trosina, Teona Shvangiradze, Pavel Bogomolov, Galina Melnichenko, Ivan Dedov.


Abstract
Objective: Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity and metabolic syndrome (MS). Liver biopsy can verify the histological form of NAFLD. The aim of the study was to evaluate the relationship between histological indicators of liver damage and metabolic parameters.
Material and methods: 80 patients, median age 45 [41.5; 47.5], with abdominal obesity and US signs of NAFLD were included in the study. All patients underwent percutaneous liver biopsy. Glucose levels during OGTT, total cholesterol, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglycerides (TG), ALT, and AST were measured. Fasting insulin, serum adiponectin, C-reactive protein (CRP) and active plasminogen antigen activator inhibitor-1 (PAI-1) were determined.
Results: NAFLD was confirmed in 77 patients (96.3%), NASH – in 64 cases (80%), steatosis - in 11 cases (13.8%). In patients with steatosis, 72.7% had dyslipidemia, 63.6% had impaired glucose metabolism, 63.6% had insulin resistance (IR); with NASH – in 93.8%, 78.1% and 100%, respectively. Adiponectin level correlated negatively with IR indicators: HOMA-IR (r = - 0.45; p = 0.023) and fasting insulin (r = - 0.35; p = 0.024). NASH patients had significantly higher levels of CRP than those with steatosis: 3.8 [2.1; 6.7] mg/L vs 1,1 [1.0; 1.7] mg/L, (p <0.0001). PAI-1 activity correlated positively with anthropometric parameters, IR, the level of CRP, and negatively with adiponectin concentration.
Conclusion: Metabolic disorders in patients with NAFLD are dependent upon the severity of the liver damage and the morphological stage of the disease.

Key words: nonalcoholic fatty liver disease, liver biopsy, abdominal obesity, cardiovascular risk factors, type 2 diabetes mellitus risk factors


 
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How to Cite this Article
Pubmed Style

Komshilova K, Mazurina N, Trosina E, Shvangiradze T, Bogomolov P, Melnichenko G, Dedov I, . METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY. Int J Surg Med. 2018; 4(4): 175-182. doi:10.5455/ijsm.Risk-factors-in-various-forms-of-NAFLD

Web Style

Komshilova K, Mazurina N, Trosina E, Shvangiradze T, Bogomolov P, Melnichenko G, Dedov I, . METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY. https://www.ejos.org/?mno=357 [Access: September 12, 2024]. doi:10.5455/ijsm.Risk-factors-in-various-forms-of-NAFLD

AMA (American Medical Association) Style

Komshilova K, Mazurina N, Trosina E, Shvangiradze T, Bogomolov P, Melnichenko G, Dedov I, . METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY. Int J Surg Med. 2018; 4(4): 175-182. doi:10.5455/ijsm.Risk-factors-in-various-forms-of-NAFLD


Vancouver/ICMJE Style

Komshilova K, Mazurina N, Trosina E, Shvangiradze T, Bogomolov P, Melnichenko G, Dedov I, . METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY. Int J Surg Med. (2018), [cited September 12, 2024]; 4(4): 175-182. doi:10.5455/ijsm.Risk-factors-in-various-forms-of-NAFLD


Harvard Style

Komshilova, K., Mazurina, . N., Trosina, . E., Shvangiradze, . T., Bogomolov, . P., Melnichenko, . G., Dedov, . I. & (2018) METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY. Int J Surg Med, 4 (4), 175-182. doi:10.5455/ijsm.Risk-factors-in-various-forms-of-NAFLD


Turabian Style

Komshilova, Ksenya, Natalya Mazurina, Ekaterina Trosina, Teona Shvangiradze, Pavel Bogomolov, Galina Melnichenko, Ivan Dedov, and . 2018. METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY. International Journal of Surgery and Medicine, 4 (4), 175-182. doi:10.5455/ijsm.Risk-factors-in-various-forms-of-NAFLD


Chicago Style

Komshilova, Ksenya, Natalya Mazurina, Ekaterina Trosina, Teona Shvangiradze, Pavel Bogomolov, Galina Melnichenko, Ivan Dedov, and . "METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY." International Journal of Surgery and Medicine 4 (2018), 175-182. doi:10.5455/ijsm.Risk-factors-in-various-forms-of-NAFLD


MLA (The Modern Language Association) Style

Komshilova, Ksenya, Natalya Mazurina, Ekaterina Trosina, Teona Shvangiradze, Pavel Bogomolov, Galina Melnichenko, Ivan Dedov, and . "METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY." International Journal of Surgery and Medicine 4.4 (2018), 175-182. Print. doi:10.5455/ijsm.Risk-factors-in-various-forms-of-NAFLD


APA (American Psychological Association) Style

Komshilova, K., Mazurina, . N., Trosina, . E., Shvangiradze, . T., Bogomolov, . P., Melnichenko, . G., Dedov, . I. & (2018) METABOLIC MARKERS OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES MELLITUS IN VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH ABDOMINAL OBESITY. International Journal of Surgery and Medicine, 4 (4), 175-182. doi:10.5455/ijsm.Risk-factors-in-various-forms-of-NAFLD


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International Journal of Surgery and Medicine E-ISSN: 2367-699X | P-ISSN: 2367-7414 International Journal of Surgery and Medicine (IJSM) is an inter ... Read more.



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